反应详情

A mixture of methyl 4′-[2-[[(benzyloxy)carbonyl]-amino]ethyl]-2-methyl-1,1′-biphenyl-4-carboxylate (650 mg), ammonium formate (500 mg) and palladium on carbon powder (400 mg) in methanol (10 ml) and water (1.0 ml) was refluxed for 2 hours. The reaction mixture was filtrated and poured into water and extracted with chloroform. The organic layer was washed with brine, dried over magnesium sulfate and evaporated to give methyl 4′-(2-aminoethyl)-2-methyl-1,1′-biphenyl-4-carboxylate (380 mg).

1. temperaturewas refluxed for 2 hours
2. filtrationThe reaction mixture was filtrated
3. additionpoured into water
4. extractionextracted with chloroform
5. washThe organic layer was washed with brine
6. dry with materialdried over magnesium sulfate
7. customevaporated