Hydrochloric Acid → HCID 69056068, compound

HRID 1866166Notes

Reaction equation

HRID 1866166 reaction equation
C([C:5]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[CH:8]=[CH:7][C:6]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH2:22][N:23](C(OC(C)(C)C)=O)[CH2:24][C@H:25]([OH:32])[C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:16][CH:15]=1)(C)(C)C.[ClH:40]>O1CCOCC1>[ClH:40].[ClH:40].[OH:32][C@H:25]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)[CH2:24][NH:23][CH2:22][CH2:21][CH2:20][C:17]1[CH:16]=[CH:15][C:14]([C:6]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][CH:5]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23569013HCID 23569013, compound

Product 1

HCID 69056068HCID 69056068, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4′-[3-[(tert-butoxycarbonyl)-[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]amino]propyl]-1,1′-biphenyl-4-carboxylic acid (90 mg) and 4N hydrochloride in dioxane (5.0 ml) was stirred at room temperature for 24 hours. The resultant solid was collected by filtration and dried to give 4′-[3-[[(2R)-2-hydroxy-2-(3-pyridyl)ethyl]-amino]propyl]-1,1′-biphenyl-4-carboxylic acid dihydrochloride (80 mg) as a white solid.

Workup

  1. filtrationThe resultant solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-f222f869272f41f2b50e7b6e34db2e7d
Source dataset
uspto-grants-2009_12
Patent number
US07629366B2

Reaction notes

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