Sodium Hydroxide → HCID 11539546, compound

HRID 1866198Notes

Reaction equation

HRID 1866198 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16](Cl)[C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:22]1([C:28]2[NH:32][C:31]([SH:33])=[N:30][CH:29]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([S:33][C:31]2[NH:32][C:28]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:29][N:30]=2)[C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 10780869Methyl 3-(4-benzyloxyphenyl)-2-chloropropanoateHCID 178527853HCID 178527853, compound

Product 1

HCID 11539546HCID 11539546, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

The solution of 0.3 g (0.001 mol) of methyl 3-[4-(benzyloxy)phenyl]-2-chloropropionate in methanol (2 ml) was added dropwise to the solution of 0.18 g (0.001 mol) 5-phenyl-1H-imidazol-2-thiol and 0.04 g (0.001 mol) of NaOH in methanol (3 ml). The solution then was heated at reflux for 5 h. The crude product obtained after removing the solvent was used without purification in the next step of the synthesis.

Workup

  1. temperatureThe solution then was heated
  2. temperatureat reflux for 5 h

Sources & evidence

ORD record
ord-f46d54faf9f74741b36ee127d6db35a2
Source dataset
uspto-grants-2009_12
Patent number
US07629370B2

Reaction notes

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