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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1866198Generated: November 4, 2026

Sodium Hydroxide → HCID 11539546, compound

https://huagongshe.com/reaction/1866198

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantMethyl 3-(4-benzyloxyphenyl)-2-chloropropanoateHCID 10780869—
ReactantHCID 178527853HCID 178527853—
SolventMethanolHCID 887—
ProductHCID 11539546HCID 11539546—

Reaction Steps

The solution of 0.3 g (0.001 mol) of methyl 3-[4-(benzyloxy)phenyl]-2-chloropropionate in methanol (2 ml) was added dropwise to the solution of 0.18 g (0.001 mol) 5-phenyl-1H-imidazol-2-thiol and 0.04 g (0.001 mol) of NaOH in methanol (3 ml). The solution then was heated at reflux for 5 h. The crude product obtained after removing the solvent was used without purification in the next step of the synthesis.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07629370B2
Source datasetuspto-grants-2009_12
ORD IDord-f46d54faf9f74741b36ee127d6db35a2
Source noteuspto-grants-2009_12