Hydrochloric Acid → HCID 9841627, compound

HRID 1866221Notes

Reaction equation

HRID 1866221 reaction equation
[F:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([C:6]([NH:20][C:21]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:22])=[N:7][N:8]2COCC[Si](C)(C)C)=[CH:4][C:3]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.Cl>CO>[F:1][C:2]1[C:10]([F:11])=[C:9]2[C:5]([C:6]([NH:20][C:21]([N:23]3[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]3)=[O:22])=[N:7][NH:8]2)=[CH:4][C:3]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86593373HCID 86593373, compound

Product 1

HCID 9841627HCID 9841627, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

80 mg of piperidine-1-carboxylic acid (6,7-difluoro-5-phenyl-1-[[2-(trimethylsilyl)-ethoxy]methyl]-1H-indazol-3-yl)amide in 2.5 ml of methanol are treated with 0.82 ml of 2N HCl for 1 hour at reflux. After evaporation and purification by preparative LC/MS (acetonitrile/pH 9 buffer), 11 mg of piperidine-1-carboxylic acid (6,7-difluoro-5-phenyl-1H-indazol-3-yl)amide are obtained.

Workup

  1. temperatureat reflux
  2. customAfter evaporation and purification by preparative LC/MS (acetonitrile/pH 9 buffer), 11 mg of piperidine-1-carboxylic acid (6,7-difluoro-5-phenyl-1H-indazol-3-yl)amide
  3. customare obtained

Sources & evidence

ORD record
ord-21c77001ea0c44f886f361f35fc1ca08
Source dataset
uspto-grants-2009_12
Patent number
US07629374B2

Reaction notes

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