huagongshe.com
HRID18665

反应详情

EQUATION

反应方程式

HRID 18665 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(N2CCOCC2)c(F)c1
HCID1485330

3-fluoro-4-morpholinoaniline

C10H13FN2O

结构：ClC[C@H]1CO1
HCID2734062

(-)-Epichlorohydrin

C3H5ClO

PRODUCTS

生成物

1
结构：O[C@@H](CCl)CNc1ccc(N2CCOCC2)c(F)c1
HCID16655948

未命名化合物

收率 99.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

3-Fluoro-4-morpholinyl aniline (39 g) is mixed with R-epichlorohydrin (18.5 g), isopropyl alcohol (200 ml) is added and heated for 16 hours at reflux temperature. The solvent is distilled to give 57 gm of N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline.

WORKUP

后处理

  1. additionis added
  2. temperatureheated for 16 hours
  3. temperatureat reflux temperature
  4. distillationThe solvent is distilled