反应详情

A mixture of 3-[3-(2-tert-butoxycarbonylamino-2-methyl-propyl)-phenyl]-acrylic acid benzyl ester (preparation 141), (2.23 g, 5.45 mmol), and trifluoroacetic acid (5 mL) in dichloromethane (10 mL) was stirred for 1 hour at room temperature. The mixture was then concentrated in vacuo and the residue was diluted with sodium hydrogen carbonate solution (10 mL) and extracted with ethyl acetate (3×20 mL). The combined organic solution was dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a yellow oil in quantitative yield.

1. concentrationThe mixture was then concentrated in vacuo
2. additionthe residue was diluted with sodium hydrogen carbonate solution (10 mL)
3. extractionextracted with ethyl acetate (3×20 mL)
4. dry with materialThe combined organic solution was dried over magnesium sulfate
5. concentrationconcentrated in vacuo