HRID1866562

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2758765

3-Ethoxyphenethylamine

C10H15NO

结构：CC(C)(Cc1cccc(C(=O)O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c(CO)c1

HCID57978309

未命名化合物

PRODUCTS

生成物

结构：CCOc1cccc(CCNC(=O)c2cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(O)c(CO)c3)c2)c1

HCID57978238

未命名化合物

收率 67%

PROCEDURE

实验过程

The title compound was prepared from 3-{2-[(2R)-2-(tert-butyldimethyl silanyloxy)-2-(4-hydroxy-3-hydroxymethyl-phenyl)ethylamino]-2-methylpropyl}benzoic acid (preparation 37) and 3-ethoxyphenethylamine, using a similar method to that of preparation 158, in 67% yield.

WORKUP

后处理

customof preparation 158

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e68e425162c340eea33a9d36ecb54473
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07629358B2
来源说明: uspto-grants-2009_12

反应 SMILES

[C:1]([Si:5]([CH3:33])([CH3:32])[O:6][C@H:7]([C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([CH2:30][OH:31])[CH:24]=1)[CH2:8][NH:9][C:10]([CH3:22])([CH3:21])[CH2:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](O)=[O:16])([CH3:4])([CH3:3])[CH3:2].[CH2:34]([O:36][C:37]1[CH:38]=[C:39]([CH:43]=[CH:44][CH:45]=1)[CH2:40][CH2:41][NH2:42])[CH3:35]>>[Si:5]([O:6][C@H:7]([C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([CH2:30][OH:31])[CH:24]=1)[CH2:8][NH:9][C:10]([CH3:22])([CH3:21])[CH2:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15]([NH:42][CH2:41][CH2:40][C:39]1[CH:43]=[CH:44][CH:45]=[C:37]([O:36][CH2:34][CH3:35])[CH:38]=1)=[O:16])([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:32])[CH3:33]