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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1866562Generated: October 26, 2026

2-(3-Ethoxyphenyl)ethan-1-amine → 3-[2-({(2R)-2{[tert-Butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)-2-methylpropyl]-N-[2-(3-ethoxyphenyl)ethyl]benzamide

https://huagongshe.com/reaction/1866562

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-Ethoxyphenyl)ethan-1-amineHCID 2758765—
Reactant3-{2-[(2R)-2-(tert-butyldimethyl silanyloxy)-2-(4-hydroxy-3-hydroxymethyl-phenyl)ethylamino]-2-methylpropyl}benzoic acidHCID 57978309—
Product3-[2-({(2R)-2{[tert-Butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)-2-methylpropyl]-N-[2-(3-ethoxyphenyl)ethyl]benzamideHCID 5797823867%

Reaction Steps

The title compound was prepared from 3-{2-[(2R)-2-(tert-butyldimethyl silanyloxy)-2-(4-hydroxy-3-hydroxymethyl-phenyl)ethylamino]-2-methylpropyl}benzoic acid (preparation 37) and 3-ethoxyphenethylamine, using a similar method to that of preparation 158, in 67% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07629358B2
Source datasetuspto-grants-2009_12
ORD IDord-e68e425162c340eea33a9d36ecb54473
Source noteuspto-grants-2009_12