Hydrochloric Acid → Methyl 1-amino-1-cyclopentanecarboxylate, HCl

HRID 1866663Notes

Reaction equation

[NH2:1][C:2]1([C:7]([OH:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.[ClH:10].[CH3:11]O>>[ClH:10].[NH2:1][C:2]1([C:7]([O:9][CH3:11])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 2901Cycloleucine

Product 1

HCID 11513856Methyl 1-amino-1-cyclopentanecarboxylate, HCl

Procedure

A solution of 1-aminocyclopentanecarboxylic acid (2.00 g, 15.5 mmol) in MeOH (30 mL) was saturated with HCl (g). The resulting mixture was aged at ambient temperature for 2 h and concentrated in vacuo to provide the title compound. MS: m/z=144 (M+1).

Workup

concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-d45b14bb48b643d29676db746d40ba19
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629338B2

Reaction notes

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