Hydrochloric Acid → Methyl 2-amino-2-ethylbutanoate hydrochloride

HRID 1866675Notes

Reaction equation

HRID 1866675 reaction equation
[NH2:1][C:2]([CH2:8][CH3:9])([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].[ClH:10].[CH3:11]O>>[ClH:10].[NH2:1][C:2]([CH2:8][CH3:9])([CH2:6][CH3:7])[C:3]([O:5][CH3:11])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 887MethanolHCID 95206alpha-Amino-2-ethylbutanoic acid

Product 1

HCID 75488114Methyl 2-amino-2-ethylbutanoate hydrochloride

Procedure

A solution of 2-amino-2-ethylbutanoic acid (3.00 g, 22.9 mmol) in MeOH (200 mL) was saturated with HCl (g). The resulting mixture was heated at reflux for 24 h, during which time it was allowed to cool to ambient temperature and was again saturated with HCl (g) twice. After 24 h at reflux, the cooled mixture was concentrated in vacuo to provide the title compound. MS: m/z=146 (M+1).

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 24 h, during which time it
  3. temperatureAfter 24 h at reflux
  4. concentrationthe cooled mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-58b00c029b784a8ca6405456282956df
Source dataset
uspto-grants-2009_12
Patent number
US07629338B2

Reaction notes

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