Hydrochloric Acid → HCID 66955314, compound

HRID 1866690Notes

Reaction equation

HRID 1866690 reaction equation
[ClH:1].[NH2:2][C:3]1([C:14]([OH:16])=[O:15])[C:11]2[C:6](=[C:7]([F:13])[CH:8]=[C:9]([F:12])[CH:10]=2)[CH2:5][CH2:4]1.Cl.[CH3:18]O>>[ClH:1].[NH2:2][C:3]1([C:14]([O:16][CH3:18])=[O:15])[C:11]2[C:6](=[C:7]([F:13])[CH:8]=[C:9]([F:12])[CH:10]=2)[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 66954941HCID 66954941, compound

Product 1

HCID 66955314HCID 66955314, compound

Procedure

A solution of 1-amino-4,6-difluoroindane-1-carboxylic acid hydrochloride (2.00 g, 15.5 mmol) in MeOH (100 mL) was saturated with HCl (g). The resulting mixture was heated at reflux for 20 h and concentrated in vacuo to provide the title compound. MS: m/z=228 (M+1).

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 20 h
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-963976c62a2047368f0731582381c0de
Source dataset
uspto-grants-2009_12
Patent number
US07629338B2

Reaction notes

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