HCID 86616406, compound → HCID 57974068, compound

HRID 1866718Notes

Reaction equation

HRID 1866718 reaction equation
[CH2:1]([C:3]12[CH2:10][CH2:9][C:6]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)([CH2:7][NH:8]1)[N:5]([CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19])[C:4]2=[O:28])[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([C:3]12[CH2:10][CH2:9][C:6]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:7][NH:8]1)[N:5]([CH2:17][C:18]([OH:20])=[O:19])[C:4]2=[O:28])[CH3:2]

Participants

5

Reactant 2

HCID 86616406HCID 86616406, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57974068HCID 57974068, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of benzyl (4-ethyl-3-oxo-1-phenyl-2,5-diazabicyclo[2.2.2]oct-2-yl)acetate from Step A (127 mg, 0.336 mmol) and 10% Pd/C (20 mg) in MeOH (5 mL) was stirred under a balloon of hydrogen. The reaction mixture was filtered and concentrated in vacuo to give the title compound. MS: m/z=289 (M+1).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2c5967d849e74bd79269c9d2a8f4a054
Source dataset
uspto-grants-2009_12
Patent number
US07629338B2

Reaction notes

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