Sulfuric Acid → Clopidogrel bisulfate

HRID 1866756Notes

Reaction equation

HRID 1866756 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]([N:13]1[CH2:21][C:17]2[CH:18]=[CH:19][S:20][C:16]=2[CH2:15][CH2:14]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=1[Cl:12])=[O:4].[S:22](=[O:26])(=[O:25])([OH:24])[OH:23]>CC(C)=O>[CH3:1][O:2][C:3]([C@@H:5]([N:13]1[CH2:21][C:17]2[CH:18]=[CH:19][S:20][C:16]=2[CH2:15][CH2:14]1)[C:6]1[C:11]([Cl:12])=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[OH:25][S:22]([OH:26])(=[O:24])=[O:23]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 60606Clopidogrel

Product 1

HCID 115366Clopidogrel bisulfateYield 88%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

This clopidogrel base was dissolved in 300 ml. acetone and mixed with 17.5 ml. Conc. Sulphuric acid under cooling. The precipitated pure Clopidogrel hydrogen sulphate was filtered and washed with acetone. The precipitate was dried in an oven at 50° C. and 105 gm.(88%) Clopidogrel hydrogen sulphate was obtained.

Workup

  1. filtrationThe precipitated pure Clopidogrel hydrogen sulphate was filtered
  2. washwashed with acetone
  3. customThe precipitate was dried in an oven at 50° C.

Sources & evidence

ORD record
ord-9cd2b4fc0cea4cb9a4281a6de61baf73
Source dataset
uspto-grants-2009_12
Patent number
US07629465B2

Reaction notes

Loading…