HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Clopidogrel Bisulfate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Clopidogrel | HCID 60606 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Clopidogrel Bisulfate | HCID 115366 | 88% |
Reaction Steps
This clopidogrel base was dissolved in 300 ml. acetone and mixed with 17.5 ml. Conc. Sulphuric acid under cooling. The precipitated pure Clopidogrel hydrogen sulphate was filtered and washed with acetone. The precipitate was dried in an oven at 50° C. and 105 gm.(88%) Clopidogrel hydrogen sulphate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07629465B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-9cd2b4fc0cea4cb9a4281a6de61baf73 |
| Source note | uspto-grants-2009_12 |