Hydrochloric Acid → HCID 68822312, compound

HRID 1866784Notes

Reaction equation

HRID 1866784 reaction equation
[ClH:1].[C:2](=[O:5])([OH:4])[NH2:3].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>C(OCC)C>[ClH:1].[C:2](=[O:4])([OH:5])[NH2:3].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21760067HCID 21760067, compound

Product 1

HCID 68822312HCID 68822312, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

With vigorous stirring hydrogen chloride in diethyl ether (about 1.4 parts by mole) was slowly added to a solution of piperidine carbamate (about 1.0 part by mole). The mixture was allowed to stir for about 8 hours before filtering and washing with diethyl ether. The white solid was further washed with dichloromethane and diethyl ether (about 1.1 ratio by volume) to remove impurities and was subsequently dried under vacuum to obtain the racemic piperidine carbamate hydrochloride salt as a white solid.

Workup

  1. filtrationbefore filtering
  2. washwashing with diethyl ether
  3. washThe white solid was further washed with dichloromethane and diethyl ether (about 1.1 ratio by volume)
  4. customto remove impurities
  5. customwas subsequently dried under vacuum

Sources & evidence

ORD record
ord-31381721116f4a9a800713605335102a
Source dataset
uspto-grants-2009_12
Patent number
US07629466B2

Reaction notes

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