Ammonium Chloride → HCID 69047085, compound

After a solution of 3-bromo-2-hydroxybenzaldehyde (1.35 g, 6.7 mmol) in THF (10 ml) was cooled to 0° C., a solution of vinyl magnesium chloride in THF (2.0M, 8.05 ml, 16.1 mmol) was added thereto under a nitrogen atmosphere over 5 minutes. The mixture was gradually warmed to room temperature and stirred at room temperature for 3 hours. The mixture was cooled to 0° C. and a 20% aqueous ammonium chloride solution (30 ml) was added thereto at 0° C. After the mixture was stirred at room temperature for 30 minutes, it was poured to ice-water (30 ml). The mixture was extracted with ethyl acetate (2×50 ml). The organic layer was combined and successively washed with water (30 ml) and a saturated aqueous NaCl solution (30 ml), followed by drying with anhydrous sodium sulfate. The solid was removed by filtration and the filtrate was concentrated to obtain a pale brown oil. This oil was purified by silica gel column chromatography (use of 40 g of Wakogel C-100E, elution with hexane:ethyl acetate=5:1) to obtain 1.24 g of 2-bromo-6-(1-hydroxy-2-propenyl)phenol.

1. temperatureThe mixture was cooled to 0° C.
2. customat 0° C
3. stirringAfter the mixture was stirred at room temperature for 30 minutes
4. extractionThe mixture was extracted with ethyl acetate (2×50 ml)
5. washsuccessively washed with water (30 ml)
6. dry with materialby drying with anhydrous sodium sulfate
7. customThe solid was removed by filtration
8. concentrationthe filtrate was concentrated
9. customto obtain a pale brown oil
10. customThis oil was purified by silica gel column chromatography (use of 40 g of Wakogel C-100E, elution with hexane:ethyl acetate=5:1)

ORD record

ord-11d36287b32149c2b438b50b9178fc22

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07629494B2