Acetonitrile → Ethyl 2-[6-azido-2-(2,4-difluorophenylamino)-5-fluoronicotinoyl]acetate

HRID 186718Notes

Reaction equation

HRID 186718 reaction equation
[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:50][C:51]#[N:52].[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[CH2:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])[cH:20][c:21]([F:25])[c:22]([OH:24])[n:23]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)(=[O:41])[N:47]=[N+:48]=[N-:49])[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[CH2:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])[cH:20][c:21]([F:25])[c:22]([N:47]=[N+:48]=[N-:49])[n:23]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 178472175Ethyl 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-hydroxynicotinoyl]acetate

Product 1

HCID 13849326Ethyl 2-[6-azido-2-(2,4-difluorophenylamino)-5-fluoronicotinoyl]acetate

Sources & evidence

ORD record
ord-80929dec7b104f6c8f82fd4f072b1b96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…