Sodium Chloride → HCID 17973404, compound

HRID 1867203Notes

Reaction equation

HRID 1867203 reaction equation
[C:1]1([CH2:7][CH2:8]/[CH:9]=[CH:10]/[C:11]([OH:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC(OCC)=O.C(N(CC)CC)C.[CH:27]1([NH2:30])[CH2:29][CH2:28]1.[Cl-].[Na+]>>[CH:27]1([NH:30][C:11](=[O:13])/[CH:10]=[CH:9]/[CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:29][CH2:28]1

Participants

6

Reactant 5

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 69828CyclopropylamineHCID 5367576(E)-5-phenylpent-2-enoic acid

Product 1

HCID 17973404HCID 17973404, compoundYield 85%

Procedure

5-Phenyl-2E-pentenoic acid 1 eq, ethyl chloroformate 1.5 eq, triethylamine 1.5 eq, cyclopropylamine 1.5 eq, quench with 10% sodium chloride solution, yield=85%.

Sources & evidence

ORD record
ord-011f8f4805b441dea3a443f1079bd780
Source dataset
uspto-grants-2009_12
Patent number
US07632531B2

Reaction notes

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