Methyl iodide → HCID 23160813, compound

HRID 1867231Notes

Reaction equation

HRID 1867231 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH3:7]I.[CH3:9][C:10]1([CH3:30])[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]([C:20]2[CH:21]=[N:22][C:23]3[C:28]([CH:29]=2)=[CH:27][CH:26]=[CH:25][CH:24]=3)[NH:11]1>CC(C)=O>[CH3:7][N:11]1[C:10]([CH3:30])([CH3:9])[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]1[C:20]1[CH:21]=[N:22][C:23]2[C:28]([CH:29]=1)=[CH:27][CH:26]=[CH:25][CH:24]=2

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 23160752HCID 23160752, compound

Product 1

HCID 23160813HCID 23160813, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Potassium carbonate (500 mg, 3.6 mmol) and methyl iodide (0.33 mL, 5.0 mmol) were added to an acetone (2 mL) solution of 3-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-yl) quinoline (144 mg, 0.5 mmol) followed by stirring for 3 hours at room temperature, filtering, concentrating the filtrate and applying the resulting residue to chromatography to obtain 60 mg of the target compound (yield: 40%).

Workup

  1. filtrationfiltering
  2. concentrationconcentrating the filtrate

Sources & evidence

ORD record
ord-3ddf265d733141b0a901b54a5e390c01
Source dataset
uspto-grants-2009_12
Patent number
US07632783B2

Reaction notes

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