反应详情

6.60 g (16.2 mmol) of N-(3-acetyl-5-benzyloxy-2-hydroxyphenyl)-2-bromo-2-methylpropionamide and 2.76 g (20 mmol) of potassium carbonate are stirred for 1 hour in 70 mL acetonitrile at reflux temperature. The solid is suction filtered, the filtrate is evaporated down, and the residue is combined with 30 mL of ethyl acetate. After fresh filtration and distilling off the solvent, the crude product is crystallized from a little methanol. Yield: 1.00 g (19%); mass spectroscopy [M+H]+=326; melting range=148° C.-150° C.

1. temperatureat reflux temperature
2. filtrationfiltered
3. customthe filtrate is evaporated down
4. filtrationAfter fresh filtration
5. distillationdistilling off the solvent
6. customthe crude product is crystallized from a little methanol