Hydrochloric Acid → HCID 21072845, compound

HRID 1867341Notes

Reaction equation

C([O:8][C:9]1[CH:10]=[C:11]([CH:20]([OH:44])[CH2:21][NH:22][C:23]([CH3:43])([CH3:42])[CH2:24][CH2:25][N:26]2[C:31]3[CH:32]=[C:33]([F:36])[CH:34]=[CH:35][C:30]=3[C:29]([CH2:39][CH3:40])([CH2:37][CH3:38])[O:28][C:27]2=[O:41])[C:12]2[O:17][CH2:16][C:15](=[O:18])[NH:14][C:13]=2[CH:19]=1)C1C=CC=CC=1.Cl>>[CH2:39]([C:29]1([CH2:37][CH3:38])[O:28][C:27](=[O:41])[N:26]([CH2:25][CH2:24][C:23]([NH:22][CH2:21][CH:20]([OH:44])[C:11]2[C:12]3[O:17][CH2:16][C:15](=[O:18])[NH:14][C:13]=3[CH:19]=[C:9]([OH:8])[CH:10]=2)([CH3:42])[CH3:43])[C:31]2[CH:32]=[C:33]([F:36])[CH:34]=[CH:35][C:30]1=2)[CH3:40]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21072811HCID 21072811, compound

Product 1

HCID 21072845HCID 21072845, compound

Procedure

The product is prepared analogously to Example 12b starting from 1-{3-[2-(6-benzyloxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-2-hydroxyethylamino]-3-methylbutyl}-4,4-diethyl-7-fluoro-1,4-dihydrobenzo[d][1,3]oxazin-2-one. Yield: 170 mg (78%; hydrochloride); HPLC-MS: Rt=10.6 min. (method A); ESI-MS: [M+H]+=516.

Workup

customThe product is prepared analogously to Example 12b

Sources & evidence

ORD record: ord-bf7fee89bfad4ee791a2444f82413aab
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07632834B2

Reaction notes

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