3-Chloro-4-fluorocinnamic acid → 1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one

HRID 1867376Notes

Reaction equation

HRID 1867376 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[F:13])/[CH:5]=[CH:6]/[C:7]([OH:9])=O.[NH:14]1[CH2:20][CH2:19][C:18](=[O:21])[NH:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:5]=[CH:6]/[C:7]([N:14]2[CH2:20][CH2:19][C:18](=[O:21])[NH:17][CH2:16][CH2:15]2)=[O:9])[CH:10]=[CH:11][C:12]=1[F:13]

Participants

3

Reactant 2

HCID 20638833-Chloro-4-fluorocinnamic acidHCID 27372641,4-Diazepan-5-one

Product 1

HCID 620467621-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one

Procedure

In analogy to the procedure described for intermediate 1A, (E)-3-chloro-4-fluorocinnamic acid and 2,3,6,7-tetrahydro-(1H)-1,4-diazepin-5(4H)-one gave the title compound as white solid. MS: 297.2 (MH+, 1Cl).

Sources & evidence

ORD record
ord-c9362d91b9cc4f3085987797719a5518
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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