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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867376Generated: October 25, 2026

3-Chloro-4-fluorocinnamic acid → 1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867376

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-4-fluorocinnamic acidHCID 2063883—
Reactant1,4-Diazepan-5-oneHCID 2737264—
Product1-[(E)-3-(3-Chloro-4-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62046762—

Reaction Steps

In analogy to the procedure described for intermediate 1A, (E)-3-chloro-4-fluorocinnamic acid and 2,3,6,7-tetrahydro-(1H)-1,4-diazepin-5(4H)-one gave the title compound as white solid. MS: 297.2 (MH+, 1Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-c9362d91b9cc4f3085987797719a5518
Source noteuspto-grants-2009_12