1,4-Diazepan-5-one → 1-[(E)-3-(4-Chloro-3-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one

HRID 1867378Notes

Reaction equation

HRID 1867378 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5](/[CH:6]=[CH:7]/[C:8]([OH:10])=O)=[CH:4][C:3]=1[F:13].[NH:14]1[CH2:20][CH2:19][C:18](=[O:21])[NH:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5](/[CH:6]=[CH:7]/[C:8]([N:14]2[CH2:20][CH2:19][C:18](=[O:21])[NH:17][CH2:16][CH2:15]2)=[O:10])=[CH:4][C:3]=1[F:13]

Participants

3

Reactant 2

HCID 27372641,4-Diazepan-5-oneHCID 57084034-Chloro-3-fluorocinnamic acid

Product 1

HCID 684321661-[(E)-3-(4-Chloro-3-fluoro-phenyl)-acryloyl]-[1,4]diazepan-5-one

Procedure

In analogy to the procedure described for intermediate 1A, (E)-4-chloro-3-fluorocinnamic acid and 2,3,6,7-tetrahydro-(1H)-1,4-diazepin-5(4H)-one gave the title compound as white solid. MS: 297.3 (MH+).

Sources & evidence

ORD record
ord-a87af4bccd0a4ca19acc41560733e115
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

Loading…