3,4-Dichlorocinnamic acid → (Rac)-1-[(e)-3-(3,4-dichloro-phenyl)-acryloyl]-3-methyl-[1,4]diazepan-5-one

HRID 1867388Notes

Reaction equation

HRID 1867388 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])/[CH:5]=[CH:6]/[C:7]([OH:9])=O.[CH3:14][CH:15]1[NH:21][C:20](=[O:22])[CH2:19][CH2:18][NH:17][CH2:16]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:5]=[CH:6]/[C:7]([N:17]2[CH2:18][CH2:19][C:20](=[O:22])[NH:21][CH:15]([CH3:14])[CH2:16]2)=[O:9])[CH:10]=[CH:11][C:12]=1[Cl:13]

Participants

3

Reactant 2

HCID 6880273,4-Dichlorocinnamic acidHCID 684340363-Methyl-1,4-diazepan-5-one

Product 1

HCID 68435157(Rac)-1-[(e)-3-(3,4-dichloro-phenyl)-acryloyl]-3-methyl-[1,4]diazepan-5-one

Procedure

In analogy to the procedure described in intermediate 1A, (E)-3,4-dichlorocinnamic acid and 3-methyl-[1,4]diazepan-5-one gave the title compound as a white solid. MS: 327.2 (MH+).

Sources & evidence

ORD record
ord-c9494c340a914e88a8a6d74f4a2e0309
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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