Hydrochloric Acid → 6-Methyl-1,4-diazepan-5-one hydrochloride

HRID 1867392Notes

Reaction equation

HRID 1867392 reaction equation
C(OC([N:8]1[CH2:14][CH:13]([CH3:15])[C:12](=[O:16])[NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:17]>>[ClH:17].[CH3:15][CH:13]1[CH2:14][NH:8][CH2:9][CH2:10][NH:11][C:12]1=[O:16]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67080775Tert-butyl 6-methyl-5-oxo-1,4-diazepane-1-carboxylate

Product 1

HCID 684349836-Methyl-1,4-diazepan-5-one hydrochlorideYield 96%

Procedure

6-Methyl-5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester (42 mg, 0.18 mmol) was suspended in hydrogen chloride solution (4 M in 1,4-dioxane, 0.5 ml) and stirred at room temperature for 4 h, then volatile material was removed by distillation, to afford the title compound (29 mg, 96%). Colorless gum, MS: 129.1 ([M−Cl]+).

Workup

  1. customvolatile material was removed by distillation

Sources & evidence

ORD record
ord-979ccf0be65149f79751c827147c3180
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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