反应详情

温度

0 °C

Benzyl-3,3-dimethyl-piperidin-4-one (WO 01/00577 A2) (5.0 g, 23 mmol) was dissolved in MeOH (25 ml), cooled to 0° C. and sodium borohydride (1.0 g, 25 mmol) was added portionwise. The reaction was allowed to reach room temperature and stirred overnight after which time the solvent was removed under vacuum, the residue redissolved in CH2Cl2, washed with water, dried (Na2SO4) and concentrated to afford the title compound (4.9 g, 97%). MS: 220.4 (MH+).

1. customto reach room temperature
2. customwas removed under vacuum
3. dissolutionthe residue redissolved in CH2Cl2
4. washwashed with water
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated