HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867397Generated: October 30, 2026
Sodium borohydride → 1-Benzyl-3,3-dimethylpiperidin-4-OL
https://huagongshe.com/reaction/1867397
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-Benzyl-3,3-dimethylpiperidin-4-one | HCID 9794413 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzyl-3,3-dimethylpiperidin-4-OL | HCID 22495720 | 97.1% |
Reaction Steps
Benzyl-3,3-dimethyl-piperidin-4-one (WO 01/00577 A2) (5.0 g, 23 mmol) was dissolved in MeOH (25 ml), cooled to 0° C. and sodium borohydride (1.0 g, 25 mmol) was added portionwise. The reaction was allowed to reach room temperature and stirred overnight after which time the solvent was removed under vacuum, the residue redissolved in CH2Cl2, washed with water, dried (Na2SO4) and concentrated to afford the title compound (4.9 g, 97%). MS: 220.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07632829B2 |
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| Source dataset | uspto-grants-2009_12 |
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| ORD ID | ord-5b8e9b4bca5b44238c29af762b0cf80a |
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| Source note | uspto-grants-2009_12 |
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