1-(2-Chloroethyl)pyrrolidine → 1-[(E)-3-(3-Chloro-phenyl)-acryloyl]-4-(2-pyrrolidin-1-yl-ethyl)-[1,4]diazepan-5-one

HRID 1867399Notes

Reaction equation

HRID 1867399 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:18][CH2:17][C:16](=[O:19])[NH:15][CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][CH:7]=1.Cl[CH2:21][CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:18][CH2:17][C:16](=[O:19])[N:15]([CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 620452481-[(E)-3-(3-Chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one

Product 1

HCID 684348611-[(E)-3-(3-Chloro-phenyl)-acryloyl]-4-(2-pyrrolidin-1-yl-ethyl)-[1,4]diazepan-5-one

Procedure

In analogy to the procedure described in intermediate 4A, 1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 3A]) and 1-(2-chloro-ethyl)-pyrrolidine gave the title compound as off-white powder. MS: 376.5 (MH+, Cl).

Sources & evidence

ORD record
ord-eb87dd7c54aa4b41ad5bc84a71ca8139
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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