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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867399Generated: October 25, 2026

1-(2-Chloroethyl)pyrrolidine → 1-[(E)-3-(3-Chloro-phenyl)-acryloyl]-4-(2-pyrrolidin-1-yl-ethyl)-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867399

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloroethyl)pyrrolidineHCID 81669—
Reactant1-[(E)-3-(3-Chloro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62045248—
Product1-[(E)-3-(3-Chloro-phenyl)-acryloyl]-4-(2-pyrrolidin-1-yl-ethyl)-[1,4]diazepan-5-oneHCID 68434861—

Reaction Steps

In analogy to the procedure described in intermediate 4A, 1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 3A]) and 1-(2-chloro-ethyl)-pyrrolidine gave the title compound as off-white powder. MS: 376.5 (MH+, Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-eb87dd7c54aa4b41ad5bc84a71ca8139
Source noteuspto-grants-2009_12