1-Acetyl-4-(2-chloroethyl)piperazine → 4-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]/[C:10]([N:12]2[CH2:18][CH2:17][C:16](=[O:19])[NH:15][CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][CH:7]=1.Cl[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]1>>[C:29]([N:26]1[CH2:27][CH2:28][N:23]([CH2:22][CH2:21][N:15]2[C:16](=[O:19])[CH2:17][CH2:18][N:12]([C:10](=[O:11])/[CH:9]=[CH:8]/[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[CH2:13][CH2:14]2)[CH2:24][CH2:25]1)(=[O:31])[CH3:30]Participants
3
Procedure
In analogy to the procedure described in intermediate 4A, 1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 3A]) and 1-[4-(2-chloro-ethyl)-piperazin-1-yl]-ethanone gave the title compound as off-white foam. MS: 433.2 (MH+, Cl).
Sources & evidence
- ORD record
- ord-8d105adabdbc4651a657d03befaa45ae
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07632829B2
Reaction notes
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