1-Acetyl-4-(2-chloroethyl)piperazine → 4-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one

Participants

Role	Name	HCID	Charge
Reactant	1-Acetyl-4-(2-chloroethyl)piperazine	HCID 13289488	—
Reactant	1-[(E)-3-(3-Chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one	HCID 62045248	—
Product	4-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one	HCID 68434933	—

Reaction Steps

In analogy to the procedure described in intermediate 4A, 1-[(E)-3-(3-chloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 3A]) and 1-[4-(2-chloro-ethyl)-piperazin-1-yl]-ethanone gave the title compound as off-white foam. MS: 433.2 (MH+, Cl).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07632829B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-8d105adabdbc4651a657d03befaa45ae
Source note	uspto-grants-2009_12