HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-(Trifluoromethyl)cinnamic acid → 4-(3-Piperidin-1-yl-propyl)-1-[(e)-3-(3-trifluoromethyl-phenyl)-acryloyl]-[1,4]diazepan-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-(Trifluoromethyl)cinnamic acid | HCID 719451 | — |
| Reactant | 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one | HCID 62044921 | — |
| Reactant | 4-(3-Piperidin-1-yl-propyl)-[1,4]diazepan-5-one dihydrochloride | HCID 67080747 | — |
| Product | 4-(3-Piperidin-1-yl-propyl)-1-[(e)-3-(3-trifluoromethyl-phenyl)-acryloyl]-[1,4]diazepan-5-one | HCID 68434413 | — |
Reaction Steps
In analogy to the procedure described in intermediate 1A, (E)-3-(trifluoromethyl)cinnamic acid and 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one-dihydrochloride (intermediate 4B, suspended in CH2Cl2 with 4 equivalent of Et3N) gave after purification on catridges, Si-Amine, 70 mL, 20 g (EtOAc) the title compound as a light yellow viscous oil. MS: 438.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632829B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-31046ed3dbd844b9a7167d70d82d4de9 |
| Source note | uspto-grants-2009_12 |