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HRID1867421

反应详情

EQUATION

反应方程式

HRID 1867421 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)/C=C/c1ccc(Cl)c(F)c1
HCID5708403

4-Chloro-3-fluorocinnamic acid

C9H6ClFO2

结构：O=C1CCN(C(=O)/C=C/c2ccc(Cl)c(Cl)c2)CCN1
HCID62044921

未命名化合物

结构：Cl.Cl.O=C1CCNCCN1CCCN1CCCCC1
HCID67080747

未命名化合物

2 次

PRODUCTS

生成物

1
结构：O=C(/C=C/c1ccc(Cl)c(F)c1)N1CCC(=O)N(CCCN2CCCCC2)CC1
HCID25032089

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

In analogy to the procedure described in intermediate 1A, 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one-dihydrochloride (intermediate 4B) and (E)-4-chloro-3-fluorocinnamic acid gave after work up with EtOAc (×3)/saturated NaHCO3 and precipitation (n-pentane) the title compound as off-white solid. MS: 422.2 (MH+, Cl).

WORKUP

后处理

  1. custom×3)/saturated NaHCO3 and precipitation (n-pentane) the title compound as off-white solid