HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chloro-3-fluorocinnamic acid → 1-[(e)-3-(4-Chloro-3-fluoro-phenyl)-acryloyl]-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chloro-3-fluorocinnamic acid | HCID 5708403 | — |
| Edukt | 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one | HCID 62044921 | — |
| Edukt | 4-(3-Piperidin-1-yl-propyl)-[1,4]diazepan-5-one dihydrochloride | HCID 67080747 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 1-[(e)-3-(4-Chloro-3-fluoro-phenyl)-acryloyl]-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one | HCID 25032089 | — |
Reaktionsschritte
In analogy to the procedure described in intermediate 1A, 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one-dihydrochloride (intermediate 4B) and (E)-4-chloro-3-fluorocinnamic acid gave after work up with EtOAc (×3)/saturated NaHCO3 and precipitation (n-pentane) the title compound as off-white solid. MS: 422.2 (MH+, Cl).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07632829B2 |
| Quelldatensatz | uspto-grants-2009_12 |
| ORD ID | ord-d726c690e4a04bd39c66861089eee542 |
| Quellennotiz | uspto-grants-2009_12 |