2-(2-Bromoethyl)oxirane → HCID 87453168, compound

HRID 1867437Notes

Reaction equation

HRID 1867437 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[NH:16][CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:22][CH2:23][CH:24]1[CH2:26][O:25]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:22][CH2:23][CH:24]3[CH2:26][O:25]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 1004142-(2-Bromoethyl)oxiraneHCID 620449211-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one2×

Product 1

HCID 87453168HCID 87453168, compound

Procedure

In analogy to the procedure described for example 166A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A) and (rac)-2-(2-bromo-ethyl)-oxirane (Journal of Organic Chemistry (1969), 34(12), 4060-5) gave after extraction with Et2O instead of EtOAc the title compound as yellow oil. MS: 383.2 (MH+, 2Cl).

Workup

  1. customgave
  2. extractionafter extraction with Et2O instead of EtOAc the title compound as yellow oil

Sources & evidence

ORD record
ord-87a28202f1494e8e99cf2364e72afb49
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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