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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1867437Generated: October 31, 2026

2-(2-Bromoethyl)oxirane → HCID 87453168, compound

https://huagongshe.com/reaction/1867437

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2-Bromoethyl)oxiraneHCID 100414—
Reactant1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62044921—
ProductHCID 87453168HCID 87453168—

Reaction Steps

In analogy to the procedure described for example 166A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A) and (rac)-2-(2-bromo-ethyl)-oxirane (Journal of Organic Chemistry (1969), 34(12), 4060-5) gave after extraction with Et2O instead of EtOAc the title compound as yellow oil. MS: 383.2 (MH+, 2Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07632829B2
Source datasetuspto-grants-2009_12
ORD IDord-87a28202f1494e8e99cf2364e72afb49
Source noteuspto-grants-2009_12