3-Hydroxypiperidine → HCID 68973451, compound

HRID 1867439Notes

Reaction equation

HRID 1867439 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH:23]3[CH2:25][O:24]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[OH:26][CH:27]1[CH2:32][CH2:31][CH2:30][NH:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH:23]([OH:24])[CH2:25][N:29]3[CH2:30][CH2:31][CH2:32][CH:27]([OH:26])[CH2:28]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 232933-HydroxypiperidineHCID 87453168HCID 87453168, compound

Product 1

HCID 68973451HCID 68973451, compound

Procedure

In analogy to the procedure described for example 167D, (rac)-1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(2-oxiranyl-ethyl)-[1,4]diazepan-5-one and 3-hydroxypiperidine gave the title compound as yellow oil. MS: 484.2 (MH+, 2Cl).

Sources & evidence

ORD record
ord-b7eab17f13bb45e7bceed699f13eacc5
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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