1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-[1,4]diazepan-5-one

Participants

Role	Name	HCID	Charge
Reactant	1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one	HCID 62044921	—
Reactant	methanesulfonic acid 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester	HCID 86615867	—
Product	1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-[1,4]diazepan-5-one	HCID 68431987	—

Reaction Steps

In analogy to the procedure described for example 167A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A]) and methanesulfonic acid 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester (prepared from 2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol and methanesulfonyl chloride) gave after reaction at RT, the title compound as an off-white foam. MS: 441.1 (MH+, 2Cl).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07632829B2
Source dataset	uspto-grants-2009_12
ORD ID	ord-fb6c81bf8963481c92c97bf53b62d513
Source note	uspto-grants-2009_12