(Z)-3-(Naphthalen-1-yl)acrylic acid → 1-((z)-3-Naphthalen-1-yl-acryloyl)-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

HRID 1867441Notes

Reaction equation

HRID 1867441 reaction equation
Cl.Cl.[N:3]1([CH2:9][CH2:10][CH2:11][N:12]2[C:18](=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[C:20]1(/[CH:30]=[CH:31]\[C:32](O)=[O:33])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1>>[C:20]1(/[CH:30]=[CH:31]\[C:32]([N:15]2[CH2:16][CH2:17][C:18](=[O:19])[N:12]([CH2:11][CH2:10][CH2:9][N:3]3[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]3)[CH2:13][CH2:14]2)=[O:33])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 12158295(Z)-3-(Naphthalen-1-yl)acrylic acidHCID 670807474-(3-Piperidin-1-yl-propyl)-[1,4]diazepan-5-one dihydrochloride2×

Product 1

HCID 684322741-((z)-3-Naphthalen-1-yl-acryloyl)-4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Procedure

In analogy to the procedure described for example 11A, 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one-dihydrochloride (intermediate 4B) and (Z)-3-naphthalen-1-yl-acrylic acid gave the title compound as light yellow foam. MS: 420.1 (MH+).

Sources & evidence

ORD record
ord-b7bde924226e45bf9b6fd528a2151f88
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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