Piperidine → HCID 68434919, compound

HRID 1867448Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH:22]3[CH2:24][O:23]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[F:8].[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH:22]([OH:23])[CH2:24][N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 8082Piperidine

HCID 87452964HCID 87452964, compound

Product 1

HCID 68434919HCID 68434919, compound

Procedure

In analogy to the procedure described for example 166B, (rac)-1-[(E)-3-(3,4-difluoro-phenyl)-acryloyl]-4-oxiranylmethyl-[1,4]diazepan-5-one and piperidine gave the title compound as light yellow viscous oil. MS: 422.2 (MH+).

Sources & evidence

ORD record: ord-53b6b4cc05be412f9771130c0bcc5e37
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07632829B2

Reaction notes

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