HCID 86604702, compound → HCID 86604701, compound

HRID 1867524Notes

Reaction equation

HRID 1867524 reaction equation
C(OC(=O)[N:10]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]3[C:24]([CH:28]=2)=[N:25][O:26][N:27]=3)=[CH:16][CH:15]=1)[CH2:11][CH2:12][F:13])C1C=CC=CC=1>[Pd]>[N:27]1[O:26][N:25]=[C:24]2[CH:28]=[C:20]([C:17]3[CH:16]=[CH:15][C:14]([NH:10][CH2:11][CH2:12][F:13])=[CH:19][CH:18]=3)[CH:21]=[CH:22][C:23]=12

Participants

3

Reactant 1

HCID 86604702HCID 86604702, compound

Product 1

HCID 86604701HCID 86604701, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

391 mg (1 mmol) (4-benzo[1,2,5]oxadiazol-5-yl-phenyl)-(2-fluoro-ethyl)-carbamic acid benzyl ester are hydrogenated in the presence of Pd/C, the reaction mixture filtered through celite and evaporated to dryness. The residues is column chromatographed (dichloromethane/petroleum ether 8:2) to yield the desired product as a yellow powder. MS(ES+): 258 (M+1).

Workup

  1. filtrationthe reaction mixture filtered through celite
  2. customevaporated to dryness
  3. customchromatographed (dichloromethane/petroleum ether 8:2)

Sources & evidence

ORD record
ord-14c86a3708f34b3dbae748b6e8137c09
Source dataset
uspto-grants-2009_12
Patent number
US07632851B2

Reaction notes

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