3-Chloro-4'-fluoro[1,1'-biphenyl]-4-carboxylic acid → HCID 67528830, compound

HRID 1867538Notes

Reaction equation

HRID 1867538 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[C:8](O)=[O:9]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][OH:9]

Participants

3

Reactant 1

HCID 463144703-Chloro-4'-fluoro[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 67528830HCID 67528830, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 3.1 g (12.4 mmol) of 3-chloro-4′-fluoro-1,1′-biphenyl-4-carboxylic acid, prepared in step 5.1., in 50 ml of tetrahydrofuran is admixed dropwise at ambient temperature with 9.3 ml (18.56 mmol) of a solution (2M) of borane-dimethyl sulphide complex in tetrahydrofuran. Stirring is continued at ambient temperature for 18 hours.

Sources & evidence

ORD record
ord-b018848bfb3b41a2b87dabeeec11185b
Source dataset
uspto-grants-2009_12
Patent number
US07632850B2

Reaction notes

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