1,1,3,3-Tetramethylguanidine → HCID 67528309, compound

HRID 1867539Notes

Reaction equation

HRID 1867539 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH2:8]Cl.[O:17]1[CH2:21][C:20](=[O:22])[NH:19][C:18]1=[O:23].CN(C)C(N(C)C)=N>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][N:19]1[C:20](=[O:22])[CH2:21][O:17][C:18]1=[O:23]

Participants

5

Reactant 3

HCID 664601,1,3,3-TetramethylguanidineHCID 973892,4-OxazolidinedioneHCID 67535740HCID 67535740, compound

Product 1

HCID 67528309HCID 67528309, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.5 g (1.96 mmol) of 3-chloro-4-(chloromethyl)-4′-fluoro-1,1′-biphenyl, prepared in step 5.3., 0.240 g (2.35 mmol) of 1,3-oxazolidine-2,4-dione and 0.45 g (3.92 mmol) of 1,1,3,3-tetramethylguanidine in 10 ml of tetrahydrofuran is refluxed for 18 hours.

Sources & evidence

ORD record
ord-2976562196ea449ba5d91919a9c4a78e
Source dataset
uspto-grants-2009_12
Patent number
US07632850B2

Reaction notes

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