1-Bromo-2-Chloroethane → HCID 67528518, compound

HRID 1867543Notes

Reaction equation

HRID 1867543 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]#[N:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Br[CH2:18][CH2:19]Cl.[OH-].[K+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3([C:15]#[N:16])[CH2:19][CH2:18]3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 14797Potassium HydroxideHCID 20099829HCID 20099829, compound

Product 1

HCID 67528518HCID 67528518, compound

Procedure

A suspension of 3.1 g (14.7 mmol) of (4′-fluoro-1,1′-biphenyl-4-yl)acetonitrile, prepared in step 7.1., 2.4 ml (29.4 mmol) of 1-bromo-2-chloroethane and 0.067 g (0.294 mmol) of N-triethylbenzylammonium chloride, heated to approximately 50° C., is admixed dropwise with 6.7 g (102.8 mmol) of aqueous 60% potassium hydroxide solution. Stirring is continued at 50° C. for 18 hours.

Workup

  1. customprepared in step 7.1

Sources & evidence

ORD record
ord-6dbd0f5738c24e578c291f59e8c58124
Source dataset
uspto-grants-2009_12
Patent number
US07632850B2

Reaction notes

Loading…