1-Bromo-2-Chloroethane → HCID 67528518, compound

Participants

Reaction Steps

A suspension of 3.1 g (14.7 mmol) of (4′-fluoro-1,1′-biphenyl-4-yl)acetonitrile, prepared in step 7.1., 2.4 ml (29.4 mmol) of 1-bromo-2-chloroethane and 0.067 g (0.294 mmol) of N-triethylbenzylammonium chloride, heated to approximately 50° C., is admixed dropwise with 6.7 g (102.8 mmol) of aqueous 60% potassium hydroxide solution. Stirring is continued at 50° C. for 18 hours.

Provenance & Evidence