Trifluoroacetic acid → Trifluoroacetic acid

HRID 1867579Notes

Reaction equation

HRID 1867579 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[NH:15]1[CH2:16][CH2:17][CH:18]([N:21]2[CH2:25][CH2:24][CH2:2][NH:23][C:22]2=[O:26])[CH2:19][CH2:20]1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 46344059tert-Butyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 155726661-(Piperidin-4-yl)-1,3-diazinan-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (0.5 mL) was added to a solution of 1-(1-t-butoxycarbonylpiperidin-4-yl)imidazolidin-2-one (20 mg, 0.07 mmol) in dichloromethane (2 mL) and the reaction stirred at room temperature overnight. The reaction was concentrated in vacuo to give the title compound as its trifluoroacetic acid salt (12 mg).

Workup

  1. concentrationThe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-5b9695d05f5d46c5aa4c11c558682937
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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