HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 2-amino-2-(4-fluorophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | (1)-4-Fluorophenylglycine | HCID 98313 | — |
| Product | Methyl 2-amino-2-(4-fluorophenyl)acetate | HCID 10943118 | — |
Reaction Steps
HCl (g) was bubbled into a solution of 4-fluoro-DL-phenylglycine (810 mg, 4.79 mmol) in methanol (20 mL) for 5 min at 0° C. The reaction warmed to ambient temperature and stirred for 18 h. The mixture was concentrated to give the title compound (1 g). MS 183.9 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632832B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-08fa690c0b1c4c05b647081e032519f7 |
| Source note | uspto-grants-2009_12 |