Water → HCID 57979569, compound

HRID 1867614Notes

Reaction equation

HRID 1867614 reaction equation
[C:1]1([N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[C:9](=[O:18])[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O>C(O)(=O)C.Cl.[Pt]=O>[C:1]1([N:7]2[CH:11]=[C:10]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[C:9](=[O:18])[NH:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 2

HCID 962WaterHCID 685657321-Phenyl-4-pyridin-4-yl-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 57979569HCID 57979569, compound

Reagents, catalysts & solvents 3

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

Platinum oxide (60 mg) was added to a solution of 1-phenyl-4-pyridin-4-yl-1,2-dihydro-3H-pyrazol-3-one (180 mg, 0.758 mmol) in acetic acid (12 mL), concentrated hydrochloric acid (0.100 mL), and water (5 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (50 psi). After 5 h the mixture was filtered and concentrated to give the title compound. MS 244.3 (M+1).

Workup

  1. customThe reaction vessel was evacuated
  2. additionback-filled with nitrogen (3×)
  3. additionback-filled with hydrogen (50 psi)
  4. filtrationAfter 5 h the mixture was filtered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-527ef4f21ce043febf36a3b1e30f01ab
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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