反应详情

Platinum oxide (60 mg) was added to a solution of 1-phenyl-4-pyridin-4-yl-1,2-dihydro-3H-pyrazol-3-one (180 mg, 0.758 mmol) in acetic acid (12 mL), concentrated hydrochloric acid (0.100 mL), and water (5 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (50 psi). After 5 h the mixture was filtered and concentrated to give the title compound. MS 244.3 (M+1).

1. customThe reaction vessel was evacuated
2. additionback-filled with nitrogen (3×)
3. additionback-filled with hydrogen (50 psi)
4. filtrationAfter 5 h the mixture was filtered
5. concentrationconcentrated